Gamma rhythms link prefrontal interneuron dysfunction with cognitive inflexibility in Dlx5/6(+/−) mice

Abnormalities in GABAergic interneurons, particularly fast-spiking interneurons (FSINs) that generate gamma (γ; ~30-120 Hz) oscillations, are hypothesized to disrupt prefrontal cortex (PFC)-dependent cognition in schizophrenia. Although γ rhythms are abnormal in schizophrenia, it remains unclear whe...

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Bibliographic Details
Published in:Neuron
Main Authors: Cho, Kathleen K.A., Hoch, Renee, Lee, Anthony T., Patel, Tosha, Rubenstein, John L.R., Sohal, Vikaas S.
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4503262/
https://ncbi.nlm.nih.gov/pubmed/25754826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2015.02.019
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