Targeting Hedgehog signaling pathway and autophagy overcomes drug resistance of BCR-ABL-positive chronic myeloid leukemia

The frontline tyrosine kinase inhibitor (TKI) imatinib has revolutionized the treatment of patients with chronic myeloid leukemia (CML). However, drug resistance is the major clinical challenge in the treatment of CML. The Hedgehog (Hh) signaling pathway and autophagy are both related to tumorigenes...

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Bibliographic Details
Published in:Autophagy
Main Authors: Zeng, Xian, Zhao, Hui, Li, Yubin, Fan, Jiajun, Sun, Yun, Wang, Shaofei, Wang, Ziyu, Song, Ping, Ju, Dianwen
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2015
Subjects:
Translational Research Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4502679/
https://ncbi.nlm.nih.gov/pubmed/25701353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/15548627.2014.994368
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