Recessive resistance to thyroid hormone in mice lacking thyroid hormone receptor beta: evidence for tissue-specific modulation of receptor function.

The diverse functions of thyroid hormone (T3) are presumed to be mediated by two genes encoding the related receptors, TRalpha and TRbeta. However, the in vivo functions of TRalpha and TRbeta are undefined. Here, we report that targeted inactivation of the mouse TRbeta gene results in goitre and ele...

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Bibliographic Details
Main Authors: Forrest, D, Hanebuth, E, Smeyne, R J, Everds, N, Stewart, C L, Wehner, J M, Curran, T
Format: Artigo
Language:Inglês
Published: 1996
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC450242/
https://ncbi.nlm.nih.gov/pubmed/8670802
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