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Identification of reproducible drug-resistance-related dysregulated genes in small-scale cancer cell line experiments
Researchers usually measure only a few technical replicates of two types of cell line, resistant or sensitive to a drug, and use a fold-change (FC) cut-off value to detect differentially expressed (DE) genes. However, the FC cut-off lacks statistical control and is biased towards the identification...
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| Pubblicato in: | Sci Rep |
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| Autori principali: | , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4502408/ https://ncbi.nlm.nih.gov/pubmed/26173481 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep11895 |
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