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Effect of Water Miscible Organic Solvents on p-Nitrophenol Hydroxylase (CYP2E1) Activity in Rat Liver Microsomes

Organic solvents used for solubilization of the substrates/NCEs are known to affect the activity of cytochrome P450 enzymes. Further, this effect varies with the solvents used, the substrates and CYP450 isoforms in question. In the present study, we have investigated the effect of ten commonly used...

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Pubblicato in:Indian J Pharm Sci
Autori principali: Patil, Pranali G., Kamble, S. H., Shah, T. S., Iyer, K. R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Medknow Publications & Media Pvt Ltd 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4502142/
https://ncbi.nlm.nih.gov/pubmed/26180273
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