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HLA-DR4-associated T- and B-cell responses to specific determinants on the IA-2 autoantigen in Type 1 diabetes

Autoantibodies to IA-2 in Type 1 diabetes are associated with HLA-DR4, suggesting influences of HLA-DR4 restricted T-cells on IA-2-specific B-cell responses. The aim of this study was to investigate possible T-B-cell collaboration by determining whether autoantibodies to IA-2 epitopes are associated...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: McLaughlin, Kerry A., Gulati, Kavita, Richardson, Carolyn C., Morgan, Diana, Bodansky, H Jonathan, Feltbower, Richard G., Christie, Michael R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4502080/
https://ncbi.nlm.nih.gov/pubmed/25225671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1301902
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