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Age-specific penetrance of LRRK2 G2019S in the Michael J. Fox Ashkenazi Jewish LRRK2 Consortium

OBJECTIVE: Estimates of the penetrance of LRRK2 G2019S vary widely (24%–100%), reflective of differences in ascertainment, age, sex, ethnic group, and genetic and environmental modifiers. METHODS: The kin-cohort method was used to predict penetrance in 2,270 relatives of 474 Ashkenazi Jewish (AJ) Pa...

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Опубликовано в: :Neurology
Главные авторы: Marder, Karen, Wang, Yuanjia, Alcalay, Roy N., Mejia-Santana, Helen, Tang, Ming-Xin, Lee, Annie, Raymond, Deborah, Mirelman, Anat, Saunders-Pullman, Rachel, Clark, Lorraine, Ozelius, Laurie, Orr-Urtreger, Avi, Giladi, Nir, Bressman, Susan
Формат: Artigo
Язык:Inglês
Опубликовано: Lippincott Williams & Wilkins 2015
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4501942/
https://ncbi.nlm.nih.gov/pubmed/26062626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0000000000001708
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