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Clonal and constricted T cell repertoire in Common Variable Immune Deficiency

We used high throughput sequencing to examine the structure and composition of the T cell receptor β chain in Common Variable Immune Deficiency (CVID). TCRβ CDR3 regions were amplified and sequenced from genomic DNA of 44 adult CVID subjects and 22 healthy adults, using a high-throughput multiplex P...

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Bibliographic Details
Published in:Clin Immunol
Main Authors: Ramesh, Manish, Hamm, David, Simchoni, Noa, Cunningham-Rundles, Charlotte
Format: Artigo
Language:Inglês
Published: 2015
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4501913/
https://ncbi.nlm.nih.gov/pubmed/25596453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clim.2015.01.002
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