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The environment of two metal ions surrounding the splice site of a group I intron.

Several divalent metal ions (Ca2+, Sr2+ and Pb2+) do not promote splicing, but instead induce cleavage at a single site in the conserved group I intron core in the absence of the guanosine cofactor at elevated pH, generating products with 5'-OH and 3'-phosphate ends. The reaction is compet...

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Publicat a:EMBO J
Autors principals: Streicher, B, Westhof, E, Schroeder, R
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 1996
Matèries:
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC450188/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8665863/
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