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Sample Size Calculation: Inaccurate A Priori Assumptions for Nuisance Parameters Can Greatly Affect the Power of a Randomized Controlled Trial

We aimed to examine the extent to which inaccurate assumptions for nuisance parameters used to calculate sample size can affect the power of a randomized controlled trial (RCT). In a simulation study, we separately considered an RCT with continuous, dichotomous or time-to-event outcomes, with associ...

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Vydáno v:PLoS One
Hlavní autoři: Tavernier, Elsa, Giraudeau, Bruno
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4501786/
https://ncbi.nlm.nih.gov/pubmed/26173007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0132578
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