Crystal structure of O-methyltransferase CalO6 from the calicheamicin biosynthetic pathway: a case of challenging structure determination at low resolution

BACKGROUND: Calicheamicins (CAL) are enedyine natural products with potent antibiotic and cytotoxic activity, used in anticancer therapy. The O-methyltransferase CalO6 is proposed to catalyze methylation of the hydroxyl moiety at the C2 position of the orsellinic acid group of CAL. RESULTS: Crystals...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:BMC Struct Biol
Autori principali: Tsodikov, Oleg V., Hou, Caixia, Walsh, Christopher T., Garneau-Tsodikova, Sylvie
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2015
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4501126/
https://ncbi.nlm.nih.gov/pubmed/26170207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12900-015-0040-6
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi