Interferon-alpha-induced phosphorylation and activation of cytosolic phospholipase A2 is required for the formation of interferon-stimulated gene factor three.

Treatment of cells with interferon (IFN)-alpha caused phosphorylation and activation of cytosolic phospholipase A2 (cPLA2). The protein tyrosine kinase Jak1 was found to be necessary for the activation of cPLA2. Jak1 could be co-immunoprecipitated with cPLA2 from cell extracts, indicating that a clo...

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Veröffentlicht in:EMBO J
Hauptverfasser: Flati, V, Haque, S J, Williams, B R
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 1996
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC450066/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8612580/
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