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The nature of inhibition of DNA gyrase by the coumarins and the cyclothialidines revealed by X-ray crystallography.

This study describes the first crystal structures of a complex between a DNA topoisomerase and a drug. We present the structures of a 24 kDa N-terminal fragment of the Escherichia coli DNA gyrase B protein in complexes with two different inhibitors of the ATPase activity of DNA gyrase, namely the co...

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Détails bibliographiques
Auteurs principaux: Lewis, R J, Singh, O M, Smith, C V, Skarzynski, T, Maxwell, A, Wonacott, A J, Wigley, D B
Format: Artigo
Langue:Inglês
Publié: 1996
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC450046/
https://ncbi.nlm.nih.gov/pubmed/8635474
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