A structural, functional, and computational analysis suggests pore flexibility as the base for the poor selectivity of CNG channels

Cyclic nucleotide-gated (CNG) ion channels, despite a significant homology with the highly selective K(+) channels, do not discriminate among monovalent alkali cations and are permeable also to several organic cations. We combined electrophysiology, molecular dynamics (MD) simulations, and X-ray cry...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Napolitano, Luisa Maria Rosaria, Bisha, Ina, De March, Matteo, Marchesi, Arin, Arcangeletti, Manuel, Demitri, Nicola, Mazzolini, Monica, Rodriguez, Alex, Magistrato, Alessandra, Onesti, Silvia, Laio, Alessandro, Torre, Vincent
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4500290/
https://ncbi.nlm.nih.gov/pubmed/26100907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1503334112
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