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The effects of chromatin organization on variation in mutation rates in the genome

The variation in local rates of mutations can affect both the evolution of genes and their function in normal and cancer cells. Deciphering the molecular determinants of this variation will be aided by resolving distinct types of mutation, since they differ in regional preferences and in association...

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Библиографические подробности
Опубликовано в: :Nat Rev Genet
Главные авторы: Makova, Kateryna D., Hardison, Ross C.
Формат: Artigo
Язык:Inglês
Опубликовано: 2015
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4500049/
https://ncbi.nlm.nih.gov/pubmed/25732611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrg3890
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