Cystic fibrosis mice carrying the missense mutation G551D replicate human genotype-phenotype correlations.

We have generated a mouse carrying the human G551D mutation in the cystic fibrosis transmembrane conductance regulator gene (CFTR) by a one-step gene targeting procedure. These mutant mice show cystic fibrosis pathology but have a reduced risk of fatal intestinal blockage compared with 'null�...

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Detalhes bibliográficos
Main Authors: Delaney, S J, Alton, E W, Smith, S N, Lunn, D P, Farley, R, Lovelock, P K, Thomson, S A, Hume, D A, Lamb, D, Porteous, D J, Dorin, J R, Wainwright, B J
Formato: Artigo
Idioma:Inglês
Publicado em: 1996
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC449990/
https://ncbi.nlm.nih.gov/pubmed/8605891
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