Cdt1-binding protein GRWD1 is a novel histone-binding protein that facilitates MCM loading through its influence on chromatin architecture

Efficient pre-replication complex (pre-RC) formation on chromatin templates is crucial for the maintenance of genome integrity. However, the regulation of chromatin dynamics during this process has remained elusive. We found that a conserved protein, GRWD1 (glutamate-rich WD40 repeat containing 1),...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Sugimoto, Nozomi, Maehara, Kazumitsu, Yoshida, Kazumasa, Yasukouchi, Shuhei, Osano, Satoko, Watanabe, Shinya, Aizawa, Masahiro, Yugawa, Takashi, Kiyono, Tohru, Kurumizaka, Hitoshi, Ohkawa, Yasuyuki, Fujita, Masatoshi
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4499137/
https://ncbi.nlm.nih.gov/pubmed/25990725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv509
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