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A variant epidermal growth factor receptor exhibits altered type alpha transforming growth factor binding and transmembrane signaling.

Epidermal growth factor (EGF) and type alpha transforming growth factor (TGF-alpha) bind to a specific region in subdomain III of the extracellular portion of the EGF receptor (EGFR). Binding leads to receptor dimerization, auto-and transphosphorylation on intracellular tyrosine residues, and activa...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Moriai, T, Kobrin, M S, Hope, C, Speck, L, Korc, M
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1994
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC44989/
https://ncbi.nlm.nih.gov/pubmed/7937865
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