Asymmetric Synthesis of Substituted Thiolanes through Domino Thia-Michael–Henry Dynamic Covalent Systemic Resolution using Lipase Catalysis

Dynamic systems based on consecutive thia-Michael and Henry reactions were generated and transformed using lipase-catalyzed asymmetric transformation. Substituted thiolane structures with three contiguous stereocenters were resolved in the process in high yields and high enantiomeric excesses.

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Detalles Bibliográficos
Publicado en:Adv Synth Catal
Autores principales: Zhang, Yan, Vongvilai, Pornrapee, Sakulsombat, Morakot, Fischer, Andreas, Ramström, Olof
Formato: Artigo
Lenguaje:Inglês
Publicado: WILEY-VCH Verlag 2014
Materias:
Communications
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4498465/
https://ncbi.nlm.nih.gov/pubmed/26190961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/adsc.201301033
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