Relationships among rat ultrasonic vocalizations, behavioral measures of striatal dopamine loss, and striatal tyrosine hydroxylase immunoreactivity at acute and chronic time points following unilateral 6-hydroxydopamine-induced dopamine depletion

Voice deficits in Parkinson disease (PD) emerge early in the disease process, but do not improve with standard treatments targeting dopamine. Experimental work in the rat shows that severe and chronic unilateral nigrostriatal dopamine depletion with 6-OHDA results in decreased intensity, bandwidth,...

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Gepubliceerd in:Behav Brain Res
Hoofdauteurs: Grant, Laura M, Barnett, David GS, Doll, Emerald J, Leverson, Glen, Ciucci, Michelle R
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4497944/
https://ncbi.nlm.nih.gov/pubmed/26026785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbr.2015.05.042
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