Structural basis of dynamic glycine receptor clustering by gephyrin

Gephyrin is a bi-functional modular protein involved in molybdenum cofactor biosynthesis and in postsynaptic clustering of inhibitory glycine receptors (GlyRs). Here, we show that full-length gephyrin is a trimer and that its proteolysis in vitro causes the spontaneous dimerization of its C-terminal...

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Autori principali: Sola, Maria, Bavro, Vassiliy N, Timmins, Joanna, Franz, Thomas, Ricard-Blum, Sylvie, Schoehn, Guy, Ruigrok, Rob W H, Paarmann, Ingo, Saiyed, Taslimarif, O'Sullivan, Gregory A, Schmitt, Bertram, Betz, Heinrich, Weissenhorn, Winfried
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2004
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC449768/
https://ncbi.nlm.nih.gov/pubmed/15201864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600256
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