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Selective permeabilization of cervical cancer cells to an ionic DNA-binding cytotoxin by activation of P2Y receptors

Extracellular ATP is known to permeabilize certain cell types to polyatomic cations like YO-PRO1. Here, we report that extracellularly applied ATP stimulated rapid uptake and accumulation of an otherwise weakly membrane permeable fluorescent DNA-binding cytotoxin, Hoechst 33258, into cervical cancer...

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Detalhes bibliográficos
Publicado no:FEBS Lett
Main Authors: Bukhari, Maurish, Deng, Han, Jones, Noelle, Towne, Zachary, Woodworth, Craig D., Samways, Damien S.K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4497545/
https://ncbi.nlm.nih.gov/pubmed/25937122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2015.04.044
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