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A general chemical synthesis platform for crosslinking multivalent single chain variable fragments
Multivalent single chain variable fragments (scFv) show increased affinity to tumor-associated antigens compared to monovalent scFv and intact monoclonal antibodies (mAb). Multivalent constructs can be derived from self-associating or covalent scFv with covalent constructs offering improved in vivo...
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| Pubblicato in: | Org Biomol Chem |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4497512/ https://ncbi.nlm.nih.gov/pubmed/22132412 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c0ob01259a |
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