Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension

Genetic evidence implicates the loss of bone morphogenetic protein type II receptor (BMPR-II) signaling in the endothelium as an initiating factor in pulmonary arterial hypertension (PAH). However, selective targeting of this signaling pathway using BMP ligands has not yet been explored as a therape...

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Publicado no:Nat Med
Main Authors: Long, Lu, Ormiston, Mark L., Yang, Xudong, Southwood, Mark, Gräf, Stefan, Machado, Rajiv D., Mueller, Matthias, Kinzel, Bernd, Yung, Lai Ming, Wilkinson, Janine M., Moore, Stephen D., Drake, Kylie M., Aldred, Micheala A., Yu, Paul, Upton, Paul D., Morrell, Nicholas W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4496295/
https://ncbi.nlm.nih.gov/pubmed/26076038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3877
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