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Intermittent dosing of rapamycin maintains antiepileptogenic effects in a mouse model of tuberous sclerosis complex

OBJECTIVE: Inhibitors of the mechanistic target of rapamycin (mTOR) pathway have antiepileptogenic effects in preventing epilepsy and pathological and molecular mechanisms of epileptogenesis in mouse models of tuberous sclerosis complex (TSC). However, long-term treatment with mTOR inhibitors may be...

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Publicado en:Epilepsia
Main Authors: Rensing, Nicholas, Han, Lirong, Wong, Michael
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4496285/
https://ncbi.nlm.nih.gov/pubmed/26122303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/epi.13031
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