Inactivation of bone morphogenetic protein 2 may predict clinical outcome and poor overall survival for renal cell carcinoma through epigenetic pathways

We investigated whether impaired regulation of bone morphogenetic protein-2 (BMP-2) via epigenetic pathways is associated with renal cell carcinoma (RCC) pathogenesis. Expression and CpG methylation of the BMP-2 gene were analyzed using RCC cell lines, and 96 matched RCC and normal renal tissues. We...

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Enregistré dans:
Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: Mitsui, Yozo, Hirata, Hiroshi, Arichi, Naoko, Hiraki, Miho, Yasumoto, Hiroaki, Chang, Inik, Fukuhara, Shinichiro, Yamamura, Soichiro, Shahryari, Varahram, Deng, Guoren, Saini, Sharanjot, Majid, Shahana, Dahiya, Rajvir, Tanaka, Yuichiro, Shiina, Hiroaki
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2015
Sujets:
Clinical Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4496240/
https://ncbi.nlm.nih.gov/pubmed/25797254
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