The combined molecular adjuvant CASAC enhances the CD8+ T cell response to a tumor-associated self-antigen in aged, immunosenescent mice

BACKGROUND: Ineffective induction of T cell mediated immunity in older individuals remains a persistent challenge for vaccine development. Thus, there is a need for more efficient and sophisticated adjuvants that will complement novel vaccine strategies for the elderly. To this end, we have investig...

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Dades bibliogràfiques
Publicat a:Immun Ageing
Autors principals: Tye, Gee Jun, Ioannou, Kyriaki, Amofah, Eunice, Quartey-Papafio, Ruby, Westrop, Samantha J., Krishnamurthy, Pramila, Noble, Alistair, Harrison, Phillip M., Gaensler, Karin M.L., Barber, Linda D., Farzaneh, Farzin
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2015
Matèries:
Short Report
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4495856/
https://ncbi.nlm.nih.gov/pubmed/26157468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12979-015-0033-0
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