Dual targeting of HER1/EGFR and HER2 with cetuximab and trastuzumab in patients with metastatic pancreatic cancer after gemcitabine failure: results of the “THERAPY”phase 1-2 trial

To improve treatment efficacy, we decided to simultaneously target HER1 and HER2 with trastuzumab and cetuximab. Following promising preclinical results, we conducted a phase 1-2 trial in advanced pancreatic cancer patients after first-line gemcitabine-based chemotherapy failure. In this single-arm,...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Assenat, Eric, Azria, David, Mollevi, Caroline, Guimbaud, Rosine, Tubiana-Mathieu, Nicole, Smith, Denis, Delord, Jean-Pierre, Samalin, Emmanuelle, Portales, Fabienne, Larbouret, Christel, Robert, Bruno, Bibeau, Frédéric, Bleuse, Jean-Pierre, Crapez, Evelyne, Ychou, Marc, Pèlegrin, André
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2015
Schlagworte:
Clinical Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4494975/
https://ncbi.nlm.nih.gov/pubmed/25918250
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