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Genetic Variation in CHI3L1 Contributes to Asthma Severity and Airway Expression of YKL-40

BACKGROUND: Single Nucleotide Polymorphisms (SNPs) in the CHI3L1 promoter, the gene encoding YKL-40, are associated with circulating YKL-40 levels and asthma prevalence. However, the effects of gene polymorphisms on asthma severity and airway expression of YKL-40 have not been examined. OBJECTIVE: D...

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Detalhes bibliográficos
Publicado no:J Allergy Clin Immunol
Main Authors: Gomez, Jose L., Crisafi, Gina M., Holm, Carole T., Meyers, Deborah A., Hawkins, Gregory A., Bleecker, Eugene R., Jarjour, Nizar, Cohn, Lauren, Chupp, Geoffrey L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4494869/
https://ncbi.nlm.nih.gov/pubmed/25592985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2014.11.027
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