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Interferon-λ4 is a cell-autonomous type III interferon associated with pre-treatment hepatitis C virus burden

Genetic variants surrounding the interferon-λ3 (IFNL3) gene are strongly associated with clearance of hepatitis C virus (HCV). A variant (rs368234815 TT/ΔG) upstream of IFNL3 was recently implicated to control expression of a novel gene termed IFNL4. We conducted genetic analysis of rs368234815 in a...

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Pubblicato in:Virology
Autori principali: Lu, Yi-Fan, Goldstein, David B., Urban, Thomas J., Bradrick, Shelton S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4494652/
https://ncbi.nlm.nih.gov/pubmed/25577150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2014.12.020
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