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MECP2, a gene associated with Rett syndrome in humans, shows conserved coding regions, independent Alu insertions, and a novel transcript across primate evolution

BACKGROUND: The methyl-CpG Binding Protein two gene (MECP2) encodes a multifunctional protein comprising two isoforms involved in nuclear organization and regulation of splicing and mRNA template activity. This gene is normally expressed in all tissues, with a higher expression level in the brain du...

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Publicat a:BMC Genet
Autors principals: Viana, Maria Carolina, Menezes, Albert Nobre, Moreira, Miguel Angelo M., Pissinatti, Alcides, Seuánez, Héctor N.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2015
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4493987/
https://ncbi.nlm.nih.gov/pubmed/26148505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12863-015-0240-x
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