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Quantitative constraint-based computational model of tumor-to-stroma coupling via lactate shuttle
Cancer cells utilize large amounts of ATP to sustain growth, relying primarily on non-oxidative, fermentative pathways for its production. In many types of cancers this leads, even in the presence of oxygen, to the secretion of carbon equivalents (usually in the form of lactate) in the cell’s surrou...
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| Publicado no: | Sci Rep |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4493718/ https://ncbi.nlm.nih.gov/pubmed/26149467 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep11880 |
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