DNA Aptamer Selected against Pancreatic Ductal Adenocarcinoma for in vivo Imaging and Clinical Tissue Recognition

In this work, we have developed a truncated DNA aptamer, termed XQ-2d, with high affinity and specificity for pancreatic ductal adenocarcinoma (PDAC). Aptamer XQ-2d selectively binds to PL45 cells with a dissociation constant in the nanomolar range, as determined by its recognition of PL45 tumor cel...

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Vydáno v:Theranostics
Hlavní autoři: Wu, Xiaoqiu, Zhao, Zilong, Bai, Huarong, Fu, Ting, Yang, Chao, Hu, Xiaoxiao, Liu, Qiaoling, Champanhac, Carole, Teng, I-Ting, Ye, Mao, Tan, Weihong
Médium: Artigo
Jazyk:Inglês
Vydáno: Ivyspring International Publisher 2015
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4493536/
https://ncbi.nlm.nih.gov/pubmed/26155314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.11938
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