Inhibition of fatty acid synthesis by expression of an acetyl-CoA carboxylase-specific ribozyme gene.
We describe the construction of ribozyme genes that are specific to acetyl-CoA carboxylase [ACC; acetyl-CoA: carbon-dioxide ligase (ADP-forming), EC 6.4.1.2] mRNAs and the effects of their expression on long-chain fatty acid synthesis. In a cell-free system, these ribozymes precisely cleave ACC mRNA...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1994
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC44935/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7937924/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.21.9951 |
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