A rodent model for Wilms tumors: embryonal kidney neoplasms induced by N-nitroso-N'-methylurea.

Embryonal kidney cell tumors develop in rats given the alkylating agent N-nitroso-N'-methylurea as neonates. These tumors resemble the childhood Wilms tumors in their histopathology. Deletions and mutations in the Wilms tumor suppressor gene, WT1, are present in up to 6% of childhood nephroblastomas...

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Опубликовано в::	Proc Natl Acad Sci U S A
Главные авторы:	Sharma, P M, Bowman, M, Yu, B F, Sukumar, S
Формат:	Artigo
Язык:	Inglês
Опубликовано:	National Academy of Sciences 1994
Предметы:	Research Article
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC44931/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7937920/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.21.9931
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