A metabolic switch toward lipid use in glycolytic muscle is an early pathologic event in a mouse model of amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is the most common fatal motor neuron disease in adults. Numerous studies indicate that ALS is a systemic disease that affects whole body physiology and metabolic homeostasis. Using a mouse model of the disease (SOD1(G86R)), we investigated muscle physiology and m...

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Publicado en:EMBO Mol Med
Autores principales: Palamiuc, Lavinia, Schlagowski, Anna, Ngo, Shyuan T, Vernay, Aurelia, Dirrig-Grosch, Sylvie, Henriques, Alexandre, Boutillier, Anne-Laurence, Zoll, Joffrey, Echaniz-Laguna, Andoni, Loeffler, Jean-Philippe, René, Frédérique
Formato: Artigo
Lenguaje:Inglês
Publicado: BlackWell Publishing Ltd 2015
Materias:
Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4492815/
https://ncbi.nlm.nih.gov/pubmed/25820275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201404433
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