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Purification and characterization of a novel excitatory peptide from Conus distans venom that defines a novel gene superfamily of conotoxins

An excitatory peptide, di16a, with 49 amino acids and ten cysteine residues was purified and characterized from the venom of Conus distans. Five AA residues were modified: one γ–carboxyglutamate (Gla), and four hydroxyproline (Hyp) residues. A cDNA clone encoding the precursor for the peptide was ch...

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Bibliographische Detailangaben
Veröffentlicht in:Toxicon
Hauptverfasser: Chen, Ping, Garrett, James E., Watkins, Maren, Olivera, Baldomero M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4492795/
https://ncbi.nlm.nih.gov/pubmed/18586046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxicon.2008.05.014
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