Calprotectin Increases the Activity of the SaeRS Two Component System and Murine Mortality during Staphylococcus aureus Infections

Calprotectin, the most abundant cytoplasmic protein in neutrophils, suppresses the growth of Staphylococcus aureus by sequestering the nutrient metal ions Zn and Mn. Here we show that calprotectin can also enhance the activity of the SaeRS two component system (TCS), a signaling system essential for...

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Publicat a:PLoS Pathog
Autors principals: Cho, Hoonsik, Jeong, Do-Won, Liu, Qian, Yeo, Won-Sik, Vogl, Thomas, Skaar, Eric P., Chazin, Walter J., Bae, Taeok
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4492782/
https://ncbi.nlm.nih.gov/pubmed/26147796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005026
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