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Antiallodynic effects of alpha lipoic acid in an optimized RR-EAE mouse model of MS-neuropathic pain are accompanied by attenuation of upregulated BDNF-TrkB-ERK signaling in the dorsal horn of the spinal cord

Neuropathic pain may affect patients with multiple sclerosis (MS) even in early disease. In an experimental autoimmune encephalomyelitis (EAE)-mouse model of MS, chronic alpha lipoic acid (ALA) treatment reduced clinical disease severity, but MS-neuropathic pain was not assessed. Hence, we investiga...

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Detalhes bibliográficos
Publicado no:Pharmacol Res Perspect
Main Authors: Khan, Nemat, Gordon, Richard, Woodruff, Trent M, Smith, Maree T
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Ltd 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4492753/
https://ncbi.nlm.nih.gov/pubmed/26171221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.137
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