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Genome Annotation by Shotgun Inactivation of a Native Gene in Hemizygous Cells: Application to BRCA2 with Implication of Hypomorphic Variants

The greatest interpretive challenge of modern medicine may be to functionally annotate the vast variation of human genomes. Demonstrating a proposed approach, we created a library of BRCA2 exon 27 shotgun-mutant plasmids including solitary and multiplex mutations to generate human knockin clones usi...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Hum Mutat
Egile Nagusiak: Ghosh, Soma, Bhunia, Anil K., Paun, Bogdan C., Gilbert, Samuel F., Dhru, Urmil, Patel, Kalpesh, Kern, Scott E.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2015
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4492117/
https://ncbi.nlm.nih.gov/pubmed/25451944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/humu.22736
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