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In vitro and in vivo identification of ABCB1 as an efflux transporter of bosutinib
BACKGROUND: Bosutinib is a recently approved ABL inhibitor. In spite of the well-documented effectiveness of BCR-ABL inhibitors in treating chronic myeloid leukemia, development of resistance is a continuous clinical challenge. Transporters that facilitate drug uptake and efflux have been proposed a...
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| Publicado no: | J Hematol Oncol |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4491863/ https://ncbi.nlm.nih.gov/pubmed/26149173 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-015-0179-4 |
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