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RB mutation and RAS overexpression induce resistance to NK cell-mediated cytotoxicity in glioma cells
Several theories aim to explain the malignant transformation of cells, including the mutation of tumor suppressors and proto-oncogenes. Deletion of Rb (a tumor suppressor), overexpression of mutated Ras (a proto-oncogene), or both, are sufficient for in vitro gliomagenesis, and these genetic traits...
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Publicado no: | Cancer Cell Int |
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Main Authors: | , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
BioMed Central
2015
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4491266/ https://ncbi.nlm.nih.gov/pubmed/26146488 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12935-015-0209-x |
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