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RB mutation and RAS overexpression induce resistance to NK cell-mediated cytotoxicity in glioma cells

Several theories aim to explain the malignant transformation of cells, including the mutation of tumor suppressors and proto-oncogenes. Deletion of Rb (a tumor suppressor), overexpression of mutated Ras (a proto-oncogene), or both, are sufficient for in vitro gliomagenesis, and these genetic traits...

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Detalhes bibliográficos
Publicado no:Cancer Cell Int
Main Authors: Orozco-Morales, Mario, Sánchez-García, Francisco Javier, Golán-Cancela, Irene, Hernández-Pedro, Norma, Costoya, Jose A., de la Cruz, Verónica Pérez, Moreno-Jiménez, Sergio, Sotelo, Julio, Pineda, Benjamín
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4491266/
https://ncbi.nlm.nih.gov/pubmed/26146488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12935-015-0209-x
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