Safety and immunologic correlates of Melanoma GVAX, a GM-CSF secreting allogeneic melanoma cell vaccine administered in the adjuvant setting

BACKGROUND: Limited adjuvant treatment options exist for patients with high-risk surgically resected melanoma. This first-in-human study investigated the safety, tolerability and immunologic correlates of Melanoma GVAX, a lethally irradiated granulocyte–macrophage colony stimulating factor (GM-CSF)-...

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Vydáno v:J Transl Med
Hlavní autoři: Lipson, Evan J, Sharfman, William H, Chen, Shuming, McMiller, Tracee L, Pritchard, Theresa S, Salas, January T, Sartorius-Mergenthaler, Susan, Freed, Irwin, Ravi, Sowmya, Wang, Hao, Luber, Brandon, Sproul, Janice Davis, Taube, Janis M, Pardoll, Drew M, Topalian, Suzanne L
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2015
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4491237/
https://ncbi.nlm.nih.gov/pubmed/26143264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-015-0572-3
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