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p35 and Rac1 underlie the neuroprotection and cognitive improvement induced by CDK5 silencing
CDK5 plays an important role in neurotransmission and synaptic plasticity in the normal function of the adult brain, and dysregulation can lead to Tau hyperphosphorylation and cognitive impairment. In a previous study, we demonstrated that RNAi knock down of CDK5 reduced the formation of neurofibril...
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| Publicado no: | J Neurochem |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4491027/ https://ncbi.nlm.nih.gov/pubmed/25864429 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.13127 |
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