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Alleged Detrimental Mutations in the SMPD1 Gene in Patients with Niemann-Pick Disease

Loss-of-function mutations in the sphingomyelin phosphodiesterase 1 (SMPD1) gene are associated with decreased catalytic activity of acid sphingomyelinase (ASM) and are the cause of the autosomal recessive lysosomal storage disorder Niemann-Pick disease (NPD) types A and B. Currently, >100 missen...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Rhein, Cosima, Mühle, Christiane, Kornhuber, Johannes, Reichel, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4490514/
https://ncbi.nlm.nih.gov/pubmed/26084044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms160613649
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