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Traction microscopy to identify force modulation in sub-resolution adhesions

We present a reconstruction algorithm that resolves cellular tractions in diffraction-limited nascent adhesions (NAs). The enabling method is the introduction of sparsity regularization to the solution of the inverse problem, which suppresses noise without underestimating traction magnitude. We show...

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Pubblicato in:Nat Methods
Autori principali: Han, Sangyoon J., Oak, Youbean, Groisman, Alex, Danuser, Gaudenz
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4490115/
https://ncbi.nlm.nih.gov/pubmed/26030446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.3430
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