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Vav1 regulates T cell activation through a feedback mechanism and crosstalk between the T cell receptor and CD28
Vavl, a Rac/Rho guanine nucleotide exchange factor and a critical component of the T cell receptor (TCR) signaling cascade, is rapidly tyrosine phosphorylated in response to T cell activation. Vav1 has established roles in proliferation, cytokine secretion, Ca(2+) responses, and actin cytoskeleton r...
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| Veröffentlicht in: | J Proteome Res |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4490005/ https://ncbi.nlm.nih.gov/pubmed/26043137 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jproteome.5b00340 |
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