An Epitope-Substituted DNA Vaccine Improves Safety and Immunogenicity against Dengue Virus Type 2

Dengue virus (DENV), a global disease, is divided into four serotypes (DENV1-4). Cross-reactive and non-neutralizing antibodies against envelope (E) protein of DENV bind to the Fcγ receptors (FcγR) of cells, and thereby exacerbate viral infection by heterologous serotypes via antibody-dependent enha...

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Vydáno v:PLoS Negl Trop Dis
Hlavní autoři: Tang, Chung-Tao, Li, Pi-Chun, Liu, I-Ju, Liao, Mei-Ying, Chiu, Chiung-Yi, Chao, Day-Yu, Wu, Han-Chung
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2015
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4489899/
https://ncbi.nlm.nih.gov/pubmed/26135599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0003903
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