Febuxostat pretreatment attenuates myocardial ischemia/reperfusion injury via mitochondrial apoptosis

BACKGROUND: Febuxostat is a selective inhibitor of xanthine oxidase (XO). XO is a critical source of reactive oxygen species (ROS) during myocardial ischemia/reperfusion (I/R) injury. Inhibition of XO is therapeutically effective in I/R injury. Evidence suggests that febuxostat exerts antioxidant ef...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Transl Med
Main Authors: Wang, Shulin, Li, Yunpeng, Song, Xudong, Wang, Xianbao, Zhao, Cong, Chen, Aihua, Yang, Pingzhen
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2015
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4489215/
https://ncbi.nlm.nih.gov/pubmed/26136232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-015-0578-x
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