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Febuxostat pretreatment attenuates myocardial ischemia/reperfusion injury via mitochondrial apoptosis
BACKGROUND: Febuxostat is a selective inhibitor of xanthine oxidase (XO). XO is a critical source of reactive oxygen species (ROS) during myocardial ischemia/reperfusion (I/R) injury. Inhibition of XO is therapeutically effective in I/R injury. Evidence suggests that febuxostat exerts antioxidant ef...
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| 出版年: | J Transl Med |
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| 主要な著者: | , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
BioMed Central
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4489215/ https://ncbi.nlm.nih.gov/pubmed/26136232 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-015-0578-x |
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