NS5A Domain 1 and Polyprotein Cleavage Kinetics Are Critical for Induction of Double-Membrane Vesicles Associated with Hepatitis C Virus Replication

Induction of membrane rearrangements in the cytoplasm of infected cells is a hallmark of positive-strand RNA viruses. These altered membranes serve as scaffolds for the assembly of viral replication factories (RFs). We have recently shown that hepatitis C virus (HCV) infection induces endoplasmic re...

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Detalhes bibliográficos
Publicado no:mBio
Main Authors: Romero-Brey, Inés, Berger, Carola, Kallis, Stephanie, Kolovou, Androniki, Paul, David, Lohmann, Volker, Bartenschlager, Ralf
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Microbiology 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4488949/
https://ncbi.nlm.nih.gov/pubmed/26152585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00759-15
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